Fresco's Waterfront Bistro is an American restaurant in St. Petersburg, FL. It carries a 4.6-star rating from 4,338 Google reviews. You will find it open 11 AM – 10 PM Monday to Thursday, with different hours on Friday, Saturday and Sunday. You will find it at 300 2nd Ave NE, St. Petersburg, FL 33701. Reach them on (727) 894-4429, or see more at frescoswaterfront.com.